![]() ![]() The use of randomized clinical trials (RCTs) has now become the gold standard for proving the efficacy and safety of novel treatments. Since the beginning of medical science, observation of the “real-world” experience has been a common traditional method to develop new medical therapies. The ultimate direction of research using the NHID should aim to improve the welfare of the public by promoting public health, reducing medical costs, and guiding healthcare policies. ![]() A step-by-step approach adopted by a team of data scientists, epidemiologists, statisticians, and clinical researchers may be most effective while designing research studies. The operational definition of covariates and clinical outcomes is important for researchers interested in using the NHID data as new tools to prove their hypothesis. Epidemiological studies, prescription patterns, temporal trends, comparison of effectiveness and safety of treatments, variability index using laboratory data, and rare intractable disease constitute interesting topics of research in cardiovascular science using the NHID. ![]() We summarized the structure of the Korean NHID and the recent researches conducted in the field of cardiovascular science. To compensate for the limitations of randomized clinical trials, real-world observational studies using claims data have emerged as a novel research tool. The Korean National Health Information Database (NHID) contains nationwide claims data, including sociodemographic data, health care utilization, health screening data, and healthcare provider information. ![]()
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